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    Medicinal Isotopes in Russia and the world: Production, Market and Forecast (5 edition)

    Number of pages: 262 Number of tables: 80 Number of figures: 22
    Language: Russian
    Released: 17.12.2021
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    This report is currently available in Russian language only. However, we can provide an English version of the report within 2 weeks after receiving a payment.

     

    This review is the 5th edition of a study of the Russian and world markets for medical isotopes.

    The aim of the study is to analyze the Russian and world markets for medical isotopes.

    This market has been monitored since 2007.

     

    The object of research is isotopes used in medicine, in particular: actinium-225, tungsten-188, gadolinium-153, germanium-68, iodine-124, iodine-125, iodine-131, oxygen-18, cobalt 60, lutetium-177 , molybdenum-99, palladium-103, ruthenium-106, samarium-153, radium-223, carbon-14, etc.

    Chronological framework of the study: 2007-2021, forecast - 2022-2027.

    Geography of research: Russian Federation - a comprehensive detailed analysis, the whole world - a brief description.

     

    This work is a desk study. The sources of information were data from the Federal State Statistics Service of the Russian Federation (Rosstat), the Federal Customs Service of the Russian Federation, the Infomine database, scientific and technical literature, industry, regional and international press, as well as Internet sites and reports of enterprises - manufacturers and consumers medico-isotope products.

     

    The report consists of an introduction and 9 chapters, contains 262 pages, including 80 tables, 22 figures and 3 appendices.

    The first chapter of the report is devoted to the study of the main areas of medical use of radioactive and stable isotopes.

    The second chapter of the report describes the main methods for obtaining radionuclides and stable isotopes.

    The third chapter of the report is devoted to the main Russian manufacturers of medical isotopes and radiopharmaceuticals; the main nomenclature of medical isotope products manufactured by them in 2007-2021 is described. The largest foreign players operating in the market are also listed.

    The fourth chapter of the report examines Russian foreign trade operations with radiopharmaceutical products and isotopic raw materials for medical purposes in 2007-2021.

    The fifth chapter of the report analyzes the prices for the main types of isotopic medical products in 2007-2021.

    The sixth chapter of the report conducted a study of the state of the modern market for medical isotopes in the world and the Russian Federation in 2021.

    The seventh chapter of the report presents data on the volumes and structure of consumption of isotope products in the healthcare of the Russian Federation in 2021.

    The eighth chapter of the report gives a forecast of the production and consumption of medical isotopes in the Russian Federation for 2022-2027.

    The ninth chapter of the report lists the main risks of nuclear medicine.

    The annexes to the report provide a register of purchases of molybdenum-99 generators in the Russian Federation in 2021, contact details of the largest Russian manufacturers and traders of medico-isotope products and a list of the main literature used.

     

    A feature of the report is the generalization of financial and production indicators of isotope products of the main Russian enterprises in this industry for 2007-2021, a detailed analysis of the dynamics of Russian export-import supplies of medical isotopes in 2007-2021, a detailed description of the range of export and import products, as well as analysis prices for isotope medical products.

     

    Target audience of the study:

    - market participants for medical isotopes - manufacturers, consumers, traders;

    - potential investors;

    - undergraduate and graduate students studying physical, chemical, biological and engineering issues of nuclear medicine.

     

    The proposed study claims to be a reference tool for marketing services and decision-makers working in the market for medical isotopes.

    Annotation

     

    Introduction

     

    1. Use of isotopes in medicine

    1.1. The main areas of medical application of radionuclides

    1.1.1. Radionuclides for diagnostics

    Single Photon Emission Computed Tomography (SPECT)

    Positron Emission Tomography (PET)

    Biochemical markers

    Magnetic resonance imaging (MRI)

    1.1.2. Therapeutic radionuclides

    Radionuclide therapy (RNT)

    Open sources of radiation

    Radioiodine therapy for thyroid cancer

    Radioiodine therapy for thyrotoxicosis

    Radionuclide therapy in the treatment of patients with bone metastases

    Implantable radioisotope current sources

    Radionuclide therapy in rheumatology. Radiosynovectomy

    1.2. Main fields of medical application of stable isotopes

    1.2.1. Diagnostic application of stable isotopes

    1.2.2. Therapeutic Uses of Stable Isotopes

    1.2.3. The use of stable isotopes for the production of radionuclides

     

    2. Methods for obtaining medical isotopes in Russia

    2.1. PET radiopharmaceutical production and GMP rules

    2.2. Basic methods for obtaining stable isotopes

    2.3. Basic methods of obtaining radionuclides

    2.3.1. Production of radionuclides in nuclear reactors

    2.3.2. Production of radioisotopes at charged particle accelerators

    2.3.3. Radionuclide generators

     

    3. Manufacturers of medico-isotope products in 2007-2021.

    3.1. The largest foreign manufacturers of medical isotopes

    3.2. Major Russian manufacturers of medical isotopes in 2007-2021

    FSUE "PO" Mayak "(Ozersk, Chelyabinsk region)

    JSC "SSC RIAR" (Dimitrovgrad, Ulyanovsk region)

    JSC "Institute of Reactor Materials" (Zarechny, Sverdlovsk region)

    JSC "Production Association" Electrochemical Plant "(Zelenogorsk, Krasnoyarsk Territory)

    FSUE "Combine" Electrokhimpribor "(Lesnoy Sverdlovsk region)

    Leningrad Nuclear Power Plant (Sosnovy Bor, Leningrad Region)

    JSC "State Research Center of the Russian Federation - Physics and Power Engineering Institute named after A. I. Leipunsky "(Obninsk, Kaluga region)

    JSC "NIFHI im. L. Ya. Karpova "(Obninsk, Kaluga region)

    CJSC "Cyclotron" (Obninsk, Kaluga region)

    JSC "Radium Institute named after V. G. Khlopin "(St. Petersburg)

    JSC "Ritvertz" (St. Petersburg)

    JSC "Siberian Chemical Combine" (Seversk, Tomsk Region)

     

    4. Export and import of medical isotopes in Russia in 2007-2021.

    4.1. Features of export-import supplies of isotopes

    JSC "Techsnabexport"

    JSC "V / O" Isotop "

    Bebig LLC / Bebig Isotopen LLC

    4.2. Export-import of main isotopes in 2007-2021

    Anonymous (or unidentified isotopes)

    Actinium-225

    Actinium-227

    Americium-241

    Bor-10

    Tungsten-188

    Gadolinium-153

    Helium-3

    Germanium-68

    Iridium-192

    Yttrium-90

    Iodine-125

    Iodine-131

    Oxygen-18

    Cobalt-57

    Cobalt 60

    Lutetium-177

    Molybdenum-99

    Palladium-103

    Radium-223

    Radium-224

    Ruthenium-106

    Samarium-153

    Strontium-82

    Strontium-89

    Strontium-90

    Carbon-13

    Carbon-14

    Phosphorus-32

    Phosphorus-33

    Cesium-131

    Cesium-137

     

    5. Price analysis of medical isotopes in the Russian Federation in 2007-2021.

    5.1. Commodity isotopes prices

    5.2. Isotope generator prices

    5.3. Isotope radiation source prices

    5.4. Prices for radiopharmaceuticals

    5.5. Isotope facilities maintenance prices

     

    6. Analysis of the current state of the market for medical isotopes

    6.1. Foreign countries

    6.2. Russian market

     

    7. Consumption of medical isotopes in the Russian Federation in 2021

     

    8. Forecast of production and consumption of medical isotopes in the Russian Federation for 2022-2027.

     

    9. Radiation risks in nuclear medicine

     

    Appendix 1: Register of purchases of technetium generators based on molybdenum-99 isotope in 2021, units, mln rubles

    Appendix 2: Contact information of the main Russian manufacturers and traders of medico-isotope products

    Appendix 3: List of main used literature

    Table 1: Main characteristics of radionuclides - γ-emitters for use in diagnostic purposes

    Table 2: Main characteristics of radionuclides - positron emitters

    Table 3: Main characteristics of radionuclides for open source therapy

    Table 4: Stable isotopes used for the production of biomedical radioisotopes

    Table 5: Most important reactor biomedical radionuclides

    Table 6: Cyclotron radionuclides

    Table 7: Target devices for producing ultrashort-lived β + emitters

    Table 8: Reactions of obtaining cyclotron radionuclides, which require an isotopically enriched target

    Table 9: Generators of medical radionuclides

    Table 10: Major foreign players in the nuclear medicine market in 2021

    Table 11: The level of production of medico-isotope products in the Russian Federation in 2021, Ci, kg, million rubles (without VAT)

    Table 12: Major Russian manufacturers of medical isotopes and product range

    Table 13: Main financial indicators of FSUE PA Mayak in 2007-2020, million rubles.

    Table 14: Main financial indicators of JSC "SSC RIAR" in 2007-2020, million rubles.

    Table 15: Main financial indicators of JSC "IRM" in 2009-2020, million rubles.

    Table 16: Main financial indicators of JSC PO EKhZ in 2007-2020, mln rub.

    Table 17: Products for nuclear medicine of the Physics and Power Engineering Institute. A. I. Leipunsky in 2019

    Table 18: Main financial indicators of JSC "SSC RF-IPPE" in 2014-2020, million rubles.

    Table 19: List of RFP produced by JSC “NIFHI im. L. Ya. Karpova "

    Table 20: Key financial indicators of JSC “NIFHI im. L. Ya. Karpova "in 2014-2020, million rubles.

    Table 21: Main financial indicators of CJSC Cyclotron in 2007-2020, million rubles.

    Table 22: Key financial indicators of JSC "Radium Institute named after V. G. Khlopin "in 2012-2020, million rubles.

    Table 23: Main financial indicators of JSC "Ritvertz" in 2007-2020, mln rub.

    Table 24: Main financial indicators of SKhK JSC in 2008-2020, billion rubles.

    Table 25: Raw isotopes, leaders in export in value terms in 2007-2021, thousand $

    Table 26: Export of sealed radiation sources for medical purposes in 2007-2021, thousand $

    Table 27: Imports of sealed sources and generators of isotopes for medical purposes in 2007-2021, thousand $

    Table 28: Financial indicators of JSC "V / O" Isotop "in 2007-2020, mln rub.

    Table 29: Companies that do not always indicate specific isotopes on export and import declarations in 2007-2021

    Table 30: Russian export of the raw isotope of actinium-225 produced by IPPE through V / O "Isotope" in 2014-2021, mCi, thousand $

    Table 31: Export of raw isotope of tungsten-188 produced by RIAR in the form of sodium tungstate solution in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 32: Export of the raw isotope gadolinium-153 produced by NIIAR in Russia in 2007-2021, Ci, thousand $

    Table 33: Export of the isotope helium-3 of the highest grade (B) with 99.99% of the isotope and 1A grade with 99.8% of the isotope produced by FSUE PA Mayak Russia in 2007-2021, g, thousand $

    Table 34: Characteristics of germanium-68 produced by ZAO "Cyclotron"

    Table 35: Export of the raw isotope germanium-68 produced by CJSC Cyclotron by Russia in 2014-2021, Ci, thousand $

    Table 36: Exports of gallium-68 generators based on the germanium-68 isotope by Russia in 2007-2021, units, Ci, thousand $

    Table 37: Import of sources for gamma therapy from the isotope iridium-192 by Russia in 2007-2021, Ci, thousand $

    Table 38: Export of yttrium-90 isotope for medical purposes (in the form of chloride solution) produced by NIIAR Russia in 2007, Ci, thousand $

    Table 39: Exports of the raw isotope iodine-125 by Russia in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 40: Import of radioimmune kits based on the iodine-125 isotope by Russia in 2007-2021, mCi, thousand $, units, thousand $ / mCi, $ / unit.

    Table 41: Imports of iodine-125 by Russia for the production of microcapsules for brachytherapy in 2014-2021, Ci, thousand $, thousand $ / Ci

    Table 42: RF imports of microcapsules for brachytherapy based on iodine-125 isotope in 2007-2021, Ki, thousand $, units

    Table 43: Exports of the raw isotope iodine-131 by Russia in 2009-2021, Ci, thousand $, $ / Ci

    Table 44: Imports of iodine-131 isotope by Russia in 2014-2021, Ci, thousand $, thousand $ / Ci

    Table 45: Imports of unregistered drug 131I-MIBG by Russia in 2014-2021, Ci, thousand $, thousand $ / Ci

    Table 46: Export of water enriched in oxygen-18 isotope, Russia in 2007-2021, kg, thousand $

    Table 47: Exports of the raw isotope cobalt-60 in 2007-2021, thousand Ci, thousand $, $ / Ci

    Table 48: Export of sources based on the isotope cobalt-60 by Russia in 2007-2021, thousand Ci, thousand $, $ / Ci

    Table 49: Russian imports of sealed sources with cobalt-60 isotope for medical equipment in 2008-2021, Ci, thousand $

    Table 50: Exports of the raw isotope of lutetium-177 by Russia in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 51: Export of molybdenum-99 isotope by Russia in 2009-2021, Ci, thousand $, $ / Ci

    Table 52: Imports of raw molybdenum-99 isotope produced by NTP Radioisotopes (South Africa) to V / O Isotope in 2007-2009, Ci, thousand $

    Table 53: Imports of technetium-99 generators based on molybdenum-99 isotope in 2014-2021, units, Ci, thousand $, thousand $ / unit

    Table 54: Export of the raw isotope palladium-103 in the form of chloride by Russia in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 55: Russian imports of the drug "Xofigo" based on the isotope radium-223 in 2014-2021, units, mCi, thousand $

    Table 56: Export of the raw isotope of ruthenium-106 in the form of chloride produced by NIIAR Russia in 2008-2021, Ci, thousand $, thousand $ / Ci

    Table 57: Import of ophthalmic applicators based on ruthenium-106 isotope produced by Eckert & Ziegler Bebig (Germany) by Russia in 2008-2021, units, mCi, thousand $, thousand $ / unit

    Table 58: Export of the raw isotope samarium-153 produced by NIFKHI to Pars (Iran) in 2016-2019, Ci, thousand $

    Table 59: Exports of raw strontium-82 isotope in the form of irradiated rubidium targets produced by the Institute for Nuclear Research of the Russian Academy of Sciences in Los Alamos National Lab. (USA) in 2014-2017, Ki, thousand $, thousand $ / Ci

    Table 60: Export of raw strontium-89 isotope in the form of chloride produced by RIAR Russia in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 61: Export of raw strontium-90 isotope by Russia in 2007-2021, Ci, thousand $

    Table 62: Russian exports and imports of gaseous carbon dioxide enriched with the isotope 13C, in 2007-2020, kg, thousand $, thousand $ / kg

    Table 63: Characteristics of 2 grades of carbon-14 isotope produced by FSUE PA Mayak

    Table 64: Export of the raw carbon-14 isotope by Russia in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 65: Export of the raw isotope phosphorus-32 by Russia in 2007-2018, Ci, thousand $

    Table 66: Imports of the raw isotope phosphorus-32 in the form of orthophosphoric acid by Russia in 2014-2015, Ci, thousand $

    Table 67: Export of the raw isotope phosphorus-33 in the form of orthophosphoric acid produced by NIIAR Russia in 2008-2012, Ci, thousand $, thousand $ / Ci

    Table 68: Export of the raw isotope cesium-131 ​​in 2007-2021, Ci, thousand $, thousand $ / Ci

    Table 69: Export of reagents based on the cesium-137 isotope by Russia in 2007-2020, Ci, thousand $, thousand $ / Ci

    Table 70: Exports of sealed sources based on the cesium-137 isotope for medical gamma devices by Russia in 2007-2021, units, Ci, thousand $

    Table 71: Imports of sealed sources based on the isotope cesium-137 for medical purposes in 2010-2019, Ci, thousand $

    Table 72: Average export prices for raw medical isotopes in 2007-2021, $ / Ci

    Table 73: Average import prices for raw isotopes for medical purposes in 2007-2021, $ / Ci

    Table 74: Average export prices for medical isotope generators in 2007-2021, $ / Ci, $ / unit

    Table 75: Average domestic purchase prices of OBP technetium generators from V / O Isotop in 2011-2021, thousand rubles / unit. VAT included

    Table 76: Average domestic prices for servicing isotope equipment in 2021, thousand rubles

    Table 77: Cost of popular medical procedures using isotopes in 2021, rubles

    Table 78: Major Isotope Therapies in High-Tech Health Care

    Table 79: Consumption of isotopic medical products in the Russian Federation in 2021, million rubles

    Table 80: Contracts of the Ministry of Health of Russia for isotope treatment of citizens of the Russian Federation abroad

    Figure 1: Diagram of the main methods for the production of isotopes

    Figure 2: Technological cycle for the production of radiopharmaceuticals

    Figure 3: Estimated shares of Russian manufacturers in the production of medical and dual-use isotopes in 2021,%

    Figure 4: Shares of the main foreign companies-buyers of Russian isotope medical products in 2015,%

    Figure 5: Shares of the main foreign companies-buyers of Russian isotope medical products in 2019,%

    Figure 6: Shares of the main foreign companies-buyers of Russian isotope medical products in 2021,%

    Figure 7: Geographic structure of Russian exports of medical isotopes in 2015,%

    Figure 8: Geographic structure of Russian exports of medical isotopes in 2019,%

    Figure 9: Geographic structure of Russian exports of medical isotopes in 2021,%

    Figure 10: Dynamics of Russian exports of isotopic medical products in 2007-2021, $ million

    Figure 11: Imports of isotopic medical products in 2007-2021, $ million

    Figure 12: Shares of the main foreign companies supplying isotopic medical products to Russia in 2015,%

    Figure 13: Shares of the main foreign companies supplying isotopic medical products to Russia in 2019,%

    Figure 14: Shares of the main foreign companies supplying isotopic medical products to Russia in 2021,%

    Figure 15: Dynamics of the average export price for Russian helium-3, grade 1A (99.8%) in 2007-2021, thousand $ / gram

    Figure 16: Dynamics of the average export price of water with 97% oxygen-18 isotope in 2007-2021, thousand $ / kg

    Figure 17: Dynamics of the average export price for carbon dioxide with 13C enrichment of more than 99% of the production of JSC PO Electrochemical Plant in 2007-2018, thousand $ / kg

    Figure 18: Dynamics of the average export and import prices for isotope iodine-131 in 2014-2021, thousand $ / Ci

    Figure 19: Dynamics of the average price of imported microcapsules for brachytherapy based on the iodine-125 isotope in 2007-2021, $

    Figure 20: Structure of consumption of isotopic medical products in the Russian Federation in 2021,%

    Figure 21: Forecast of the production of raw isotopes for medical purposes in the Russian Federation for 2022-2027, billion rubles

    Figure 22: Forecast of the production of isotopic medical products (RFP, isotope generators, radiation sources, calibration sources, working gases for MRI) in the Russian Federation for 2022-2027, billion rubles 

     

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