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    Medicinal Isotopes in Russia: Production, Market and Forecast (3rd edition)

    Number of pages: 254 Number of tables: 95 Number of figures: 38
    Language: Russian
    Released: 25.05.2016
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    Price: 3 000 Euro

    This report is currently available in Russian language only. However, we can provide an English version of the report within 3 weeks after receiving a payment.

     

    This review is the 3rd edition of the study of the Russian market of isotopes of medical purpose.

    The purpose of research – analysis of the Russian market of isotopes of medical purpose.

    Monitoring of the market since 2007

    The object of research is industrial isotopes used in medicine: Actinium-225, Americium-241, Boron-10, Tungsten-188, Gadolinium-153, Helium-3 Germanium-68, Iron-55, Iridium-192, Yttrium-90, Ytterbium-169, Iodine-124, Iodine-125, Iodine-131, CA-252, Oxygen-18, Cobalt-57, Cobalt 60, krypton-85, Xenon-129, Lutetium-177 Manganese-54, Molybdenum-99 Sodium-22 Nickel-63, Tin-117m, Palladium-103, radium-223, Ruthenium-106, Samarium-153, Strontium-82, Strontium-89, Strontium-90, Carbon-13, Carbon-14, Phosphorus-32, Phosphorus-33, Cesium-131, Cesium-137.

    The chronological scope of the study: 2007-2015, forecast 2016-2025

    Geography research: Russian Federation – a comprehensive detailed analysis of the characteristics.

     

    This work is a Desk study. As information sources used data of Rosstat, Federal customs service of Russia, scientific-technical literature, sectoral, regional and international Newspapers as well as Internet-sites of company − producers and consumers of medical-isotope production.

     

    The report consists of an introduction and 5 chapters, contains 254 pages including 95 tables, 38 figures and 2 appendices.

    The first Chapter is devoted to the major fields of medical applications of radioactive and stable isotopes. This Chapter describes the most widely used for diagnostic and therapeutic purposes stable isotopes and radionuclides, the basic methods of nuclear medicine and describes the most promising isotopes for the further development of nuclear biomedical technologies.

    In the second Chapter of the report describes the main methods of obtaining radionuclides and stable isotopes. This Chapter describes the most widely used in industry methods of isotope separation, are the most important biomedical reactor and cyclotron radionuclides, the basic nuclear reactions of their receipt, and describes the short-lived radionuclide generators, currently used for medical purposes in Russia and abroad.

    The third Chapter is devoted to producers of medical isotopes and radiopharmaceuticals, described in the main item manufactured of medical-isotope production. The estimates of production in Russia, as a raw material of medical isotopes, and the isotope production (in physical and money terms) and specified shares of the main manufacturers.

    The fourth Chapter discusses the Russian foreign trade operations with radiopharmaceutical isotope production and raw materials of medical purpose. In addition, this Chapter provides an analysis of the dynamics of the Russian export-import supplies of medical isotopes for the last 9 years in monetary terms, detailed nomenclature of export and import products, data on the main exporters and importers of medical-isotope production in Russia.

    In the fifth Chapter a study of the condition of modern market of isotopes of medical purpose. Given the forecast development in 2016-2025.

    In the annexes to the report contained the text of the order of the Government of the Russian Federation on the development of the concept for nuclear medicine development until 2020, contact details of major Russian producers and traders of medical-isotope production and the list of the used literature.

     

    Target audience research:

    - parties market of isotopes of medical purpose – producers, consumers, traders;

    - potential investors.

    The proposed study claims the role of reference for marketing services and specialists taking management decisions, working in the market of isotopes of medical purpose.

    Abstract

     

    Introduction

     

    1. The use of isotopes in medicine

    1.1. The main areas of medical use of radionuclides

    1.1.1. Radionuclides for diagnostics

    Single photon emission computed tomography (SPECT)

    Positron emission tomography (PET)

    Markers for biochemical analysis

    Magnetic resonance imaging (MRI)

    1.1.2. Radionuclides for therapeutic purpose

    Radionuclide therapy (RNT)

    Open sources of radiation

    Implantable radioisotope power sources

    Radioiodine therapy for thyroid cancer

    Radioiodine therapy for hyperthyroidism

    Radionuclide therapy in the treatment of patients with bone metastases

    Radionuclide therapy in rheumatology. Radiosynovectomy

    1.2. The main areas of medical applications of stable isotopes

    1.2.1. Diagnostic application of stable isotopes

    1.2.2. The therapeutic use of stable isotopes

    1.2.3. The use of stable isotopes to obtain radionuclides

     

    2. Methods of producing isotopes for medical purposes in Russia

    2.1. The manufacture of PET radiopharmaceuticals

    2.2. Production of PET radiopharmaceuticals and GMP rules

    2.3. Registration of PET radiopharmaceuticals

    2.4. Preclinical trials

    2.5. The main methods of obtaining stable isotopes

    2.6. The main methods of obtaining radionuclides

    2.6.1. The production of radionuclides in nuclear reactors

    2.6.2. Receipt of radioisotopes in charged particle accelerators

    2.6.3. Generators of radionuclides

     

    3. Manufacturers of medical-isotope production

    3.1. The largest foreign producers of isotopes for medical purposes

    3.2. The main Russian producers of medical isotopes

    FSUE "PO "Mayak" (Ozersk, Chelyabinsk region)

    JSC "SSC RIAR" (Dimitrovgrad, Ulyanovsk region)

    JSC "Institute of Reactor Materials (Zarechny, Sverdlovsk region)

    JSC "radium Institute. V. Khlopin (Saint Petersburg)

    JSC "Production Association "Electrochemical plant" (Zelenogorsk, Krasnoyarsk region)

    FGUP "Kombinat Elektrokhimpribor" (Lesnoy, Sverdlovsk region)

    Leningrad Nuclear power Plant (Sosnovy Bor, Leningrad region)

    JSC "SSC RF Physical-energetic Institute. A. I. Leypunsky" (Obninsk, Kaluga region)

    The Obninsk branch of nifkhi im. Karpov

    JSC "Siberian chemical combine" (Seversk, Tomsk region)

    JSC "NIKIET" (Moscow)

    Fsbi "research center "Kurchatov Institute" (Moscow)

    FSUE "Federal center for design and development of nuclear medicine" FMBA Russia

    Fsbi "Russian scientific center of radiology and surgical technologies (Saint Petersburg)

    Physico-technical Institute at Tomsk Polytechnic University (Tomsk)

    Ural Federal University named after first President of Russia B. N. Yeltsin (Ekaterinburg)

    JSC "Cyclotron"

     

    4. Export and import of isotopes of medical purpose in Russia

    4.1. Features of export-import supplies of isotopes

    JSC "Techsnabexport"

    JSC "V/O "Isotope"

    4.2. Export-import of certain isotopes in 2007-2015

    Anonymous (or not identified isotopes)

    Actinium-225

    Americium-241

    Boron-10

    Tungsten-188

    Gadolinium-153

    Helium-3

    Germanium-68

    Iron-55

    Iridium-192

    Yttrium-90

    Ytterbium-169

    Iodine-124

    Iodine-125

    Iodine-131

    California-252

    Oxygen-18

    Cobalt-57

    Cobalt 60

    Krypton-85

    Xenon-129

    Lutecium-177

    Manganese-54

    Molybdenum-99

    Sodium-22

    Nickel-63

    Tin-117m

    Palladium-103

    Radium-223

    Ruthenium-106

    Samarium-153

    Strontium-82

    Strontium-89

    Strontium-90

    Carbon-13

    Carbon-14

    Phosphorus-32

    Phosphorus-33

    Cesium-131

    Cesium-137

     

    5. Analysis of the condition of the modern market of isotopes of medical purpose

    5.1. Foreign countries

    5.2. The Russian Market

     

    Appendix 1: Action Plan ("roadmap") "Development of centers of nuclear medicine"

    Appendix 2: contact information on main Russian producers and traders of medical-isotope production

    The list of the used literature

    Table 1: Main characteristics of radionuclides – γ-emitters for use in diagnostic purposes

    Table 2: Main characteristics of radionuclides – positron emitters

    Table 3: Main characteristics of radionuclides for therapy of open sources

    Table 4: Stable isotopes used to produce radioisotopes for biomedical applications

    Table 5: the Most important biomedical reactor radionuclides

    Table 6: radionuclides Cyclotron

    Table 7: Target devices for receiving the ultra β+-emitters

    Table 8: the Reaction for producing cyclotron radionuclides that require target isotopologues

    Table 9: Generators of radionuclides for medical purposes

    Table 10: estimated production Levels of key medical isotopes in Russia in 2015, Ki, kg, mln RUB (without VAT)

    Table 11: estimated Level of production of the medical isotope products in the Russian Federation in 2015, Ki, kg, mln RUB (without VAT)

    Table 12: Major Russian manufacturers of isotopes of medical purpose and the range of products

    Table 13: Key financial indicators of JSC "SSC RIAR" in 2007-2015, mln.

    Table 14: Key financial indicators of JSC "IRM" in 2009-2015, mln.

    Table 15: Financial results "ECP" in 2008-2015, million rubles.

    Table 16: Products for nuclear medicine physics and energy Institute. A. I. Leypunsky in 2013

    Table 17: List of RFP, which in Obninsk branch of nifkhi im. Karpov licensed

    Table 18: Key financial indicators of JSC "Institute of physical chemistry them. Karpov" in 2013-2015, mln.

    Table 19: Key financial indicators of JSC "SGChE" in 2007-2015, RUB bln.

    Table 20: Key financial indicators of JSC "NIKIET" in 2009-2015, mln.

    Table 21: Russian developers and manufacturers of radiopharmaceuticals and the main nomenclature of manufactured products

    Table 22: Commodity isotopes, the leading exporter in value terms (top 10) in 2007-2015, thousand $

    Table 23: Summary table of exports of sealed sources for medical purposes in 2007-2015, thousand $

    Table 24: export Destinations of isotope-medical products from Russia in 2007-2015, thousand $

    Table 25: Summary table of import of sealed sources and generators of isotopes for medical purposes in 2007-2015, thousand $

    Table 26: Directions of import of isotope-medical products in Russia in 2007-2015, thousand $

    Table 27:Financial indicators of JSC "V/O "Isotope" in 2008-2015, million rubles.

    Table 28: Organisations do not always indicate specific isotopes in export and import declarations in 2007-2015

    Table 29: Characteristics of the raw isotope actinium-225 produced by IPPE (Obninsk)

    Table 30: Russian exports of raw isotope actinium-225 production using IPPE V/O "Isotope" in 2014-2015, Kee, $thousand

    Table 31: Exports of dioxide americium-241 Russia in 2007-2015, Key, thousand $

    Table 32: Specification of Russian isotope americium-241, sold through the company Raims (England) in 2016

    Table 33: Import of boron-10 isotope produced by "national high technology centre of Georgia by Russia in 2007-2015, kg, thousand $

    Table 34: commodity Export isotope tungsten-188 production RIAR in the form of a solution of tungstate of sodium to Russia in 2007-2015, Key, thousand $

    Table 35: Exports of generators for rhenium-188 on the basis of isotope tungsten-188 production, IPPE (Obninsk) through the V/O "Isotope" in 2015

    Table 36: Exports of primary isotope gadolinium-153 production RIAR Russia in 2007-2015, Key, thousand $

    Table 37: Export of sealed sources based on the isotope gadolinium-153 type ФГ153М13.410 production RIAR Russia in 2007-2015, units, Kee, $ thousand

    Table 38: imports of sealed sources based on the isotope gadolinium-153 from United States production of Eckert&Ziegler Isotope Products brand CAS: 58023-33-9 and CAS:15756-77-1 in 2007-2015, units, Kee, $ thousand

    Table 39: Exports of the isotope helium-3, the highest grade (b) from 99.99% of the isotope and 1A grade with 99.8% of the isotope production "Mayak", Russia in 2007-2015, t, thousand $

    Table 40: Russian Specification for helium-3 sold through Russian firm Raims in 2016

    Table 41: characteristics of germanium-68 manufactured by JSC "Cyclotron"

    Table 42:Exports of primary isotope germanium-68 manufactured by JSC "Cyclotron" Russia in 2007-2015, Key, thousand $

    Table 43:Exports of generators and of gallium-68 on the basis of the isotope germanium-68 Russia in 2007-2015, units, Kee, $ thousand

    Table 44:Imports of generators with the isotope germanium-68 from Eckert & Ziegler Isotope Products GmbH (Germany) by Russia in 2007-2015, Key, thousand $

    Table 45: Exports of primary isotope iron-55 Russia in 2007-2015, Key, thousand $

    Table 46: Exports of needles of the isotope iridium-192 for medical purposes in Russia in 2007-2015, Key, thousand $

    Table 47: Import sources for gamma therapy of the isotope iridium-192 Russia in 2007-2015, Key, thousand $

    Table 48: Exports of the isotope yttrium-90 for medical purposes (in the form of chloride solution) produced by RIAR, Russia in 2007. Key, thousand $

    Table 49: Exports of primary isotope of ytterbium-169 for medical purposes (in the form of solid oxide) production in RIAR address of the Institute "Polat" (Poland) in 2007-2015, Key, thousand $

    Table 50: Exports of primary isotope iodine-124 produced by JSC "Rivers" Russia in 2007-2015, Key, thousand $

    Table 51: Exports of primary isotope iodine-125 by Russia in 2007-2015, Key, thousand $

    Table 52: Import of radioimmunoassay kits on the basis of the isotope iodine-125 by Russia in 2007-2015, MkI, $thousand.

    Table 53: Russian Imports of iodine-125 in the technical containers for the production of microcapsules for brachytherapy in 2014-2015, Kee, $thousand

    Table 54: Russian Imports of microcapsules for brachytherapy on the basis of the isotope iodine-125 in 2007-2015, Key, $thousand.

    Table 55: Exports of primary isotope iodine-131 production RIAR Russia in 2009-2010, Kee, $thousand

    Table 56: Russian Imports of products on the basis of the isotope iodine-131 in 2014-2015, Kee, $thousand

    Table 57: Exports of the isotope CA-252 for medical purposes in Russia in 2008-2015, MCI, thousand $

    Table 58: Exports of water enriched in the isotope oxygen-18, manufactured by JSC "Global scientific technology" by Russia in 2007-2015, kg, thousand $

    Table 59: Export of gamma-ray sources on the basis of the isotope cobalt-57 Russia in 2007-2015, Key, thousand $

    Table 60: Exports V/O "Isotope" raw isotope cobalt-57, in the form of chloride of production of JSC "Cyclone" in 2014-2015, Kee, $ thousand

    Table 61: Export of primary isotope is cobalt-60 production of Leningrad NPP in the address Nordion (Canada) in 2007-2015, thousand Kee, $ thousand

    Table 62: Export of sources based on the isotope cobalt-60 Russia in 2007-2015, thousand Kee, $ thousand

    Table 63: Russian Imports of sealed sources with isotope 60Co for radiotherapy equipment in 2007-2015, Key, thousand $

    Table 64: Exports of raw isotope isotope krypton-85 production AT Mayak, Russia in 2007-2015, Key, thousand $

    Table 65: Specification for Russian krypton-85 sold through the company Raims (England)

    Table 66: Exports of the isotope xenon-129 production ECP Russia in 2007-2015, Key, thousand $

    Table 67: Exports of primary isotope lutetium-177 Russia in 2007-2015, Key, thousand $

    Table 68: Exports of primary isotope manganese-54 production RIAR Russia in 2007-2015, Key, thousand $

    Table 69: Exports of the isotope molybdenum-99 Russia in 2009-2015, Kee, $thousand

    Table 70: Import of raw isotope molybdenum-99 production NTP Radioisotopes (South Africa) to address V/O "Isotope" in 2007-2009, Kee, $thousand

    Table 71: Import of generators of technetium-99 stamps "Polenak" produced by Polatom (Poland) in 2007-2015, pieces, kg, Ki, $ thousand

    Table 72: Exports of the isotope sodium-22 Russia in 2008 and in 2010, Ki, $

    Table 73: Import of calibration sources for PET/CT scanners on the basis of the isotope sodium-22 in 2009-2015, MkI, $

    Table 74: Exports of primary isotope Nickel-63 Russia in 2007-2015, Key, thousand $

    Table 75: Export of raw isotope tin-117m in the form of chloride production RIAR Russia in 2007-2009, Kee, $ thousand

    Table 76: the Export of raw isotope palladium-103 in the form of chloride by Russia in 2007-2015, Key, thousand $

    Table 77: Russian Imports of the drug "Alpharadin" on the basis of the isotope radium-223 in 2014-2015, PCs, MkI, thousand $

    Table 78: Exports of primary isotope ruthenium-106 in the form of chloride production RIAR Russia in 2008-2015, Kee, $ thousand

    Table 79: Import of ofthalmoplegical on the basis of the isotope ruthenium-106 production of Eckert & Ziegler, Bebig Russia in 2008-2015, units, Kee, $ thousand

    Table 80: Exports of primary isotope strontium-82 in the form of irradiated rubidium target production of the Institute for nuclear studies at Los Alamos National Lab. (USA) in 2014-2015, Kee, $ thousand

    Table 81: Exports of primary isotope strontium-89 in the form of chloride production RIAR Russia in 2008-2015, Kee, $ thousand

    Table 82: Exports of primary isotope strontium-90 in different nomenclature by Russia in 2007-2015, Key, thousand $

    Table 83: Standard specification for raw isotope strontium-90 in the form of carbonate of Russian production from the British company Raims Ltd.

    Table 84: Russian exports and imports of gaseous carbon dioxide enriched with the isotope 13C, in 2007-2015, kg, thousand $

    Table 85: Exports of primary isotope carbon-14 in different nomenclature by Russia in 2007-2015, Key, thousand $

    Table 86: Export of raw isotope porcelain-32 Russia in 2007-2012, Key, thousand $

    Table 87: Import of raw isotope porcelain-32 in the form of phosphoric acid by Russia in 2014-2015, Kee, $ thousand

    Table 88: Exports of primary isotope forfor-33 in the form ortofosfornoj acid production RIAR Russia in 2008-2012, Kee, $ thousand

    Table 89: Exports of primary isotope cesium-131 production IWW and RIAR to address Isoray Medical Inc. (USA) in 2007-2015, Key, thousand $

    Table 90: Exports of reagents on the basis of the isotope cesium-137 Russia in 2007-2015, Key, thousand $

    Table 91: the Export of sealed sources on the basis of the isotope cesium-137 production "Mayak" for medical gamma-devices Russia in 2007-2015, units, Kee, $thousand

    Table 92: Average export price of the main sources of medical radiation exposure to cesium-137 in the period 2007-2015, thousand $/PCs.

    Table 93: Import of sealed sources on the basis of the isotope cesium-137 for medical purposes in 2010-2012, Ki, $ thousand

    Table 94: Number of nuclear medicine procedures that are performed in some countries of the world (in year 1000) in 2015

    Table 95: Principal therapy using isotopes in the framework of high-tech medical care

    Figure 1: Scheme of the main methods of production of isotopes

    Figure 2: Technological cycle of radiopharmaceuticals

    Figure 3: Estimated share of manufacturers in the production of medical isotopes RF and dual use in 2015, %

    Figure 4: shares of major foreign firms-buyers of Russian production of isotopes for medical purposes in 2015, %

    Figure 5: the Structure of Russian exports of medical isotopes to 2015 by country, %

    Figure 6: Dynamics of Russian exports of isotope-medical products in 2007-2015, thousand $

    Figure 7: Dynamics of Russian import of isotope-medical products in 2007-2015, thousand $

    Figure 8: shares of major foreign companies-suppliers of isotope products for medical purposes in Russia in 2015, %

    Figure 9: Main destinations imports of medical isotopes in Russia in 2015, %

    Figure 10: Commodity structure of export of medical products V/O "Isotope" in 2015, %

    Figure 11: Geography of exports of health care products V/O "Isotope" in 2015, %

    Figure 12: Comparison of alpha - and beta-irradiation of cancer cells and healthy tissues

    Figure 13: Scheme of monoclonal antibodies with the RP on the basis of actinium-225

    Figure 14: Average export price dioxide americium-241 grade "A" in 2007-2015, thousand $ /Key

    Figure 15: the Average import price of Georgian amorphous boron -10 enrichment 95.5 per cent in 2007-2015, thousand $ /kg

    Figure 16: Dynamics of export of raw isotope tungsten-188 production RIAR Russia in 2007-2015, Ki

    Figure 17: Dynamics of export of raw isotope gadolinium-153 production RIAR Russia in 2007-2015, Ki

    Figure 18: Dynamics of export of the isotope helium-3 (total grade "B" grade "1A" and others) by Russia in 2007-2015, grams/year

    Figure 19: Average export price of Russian helium-3 grade "1A" (99.8 percent) in 2007-2015, thousand $ /gram

    Figure 20: Dynamics of decline in average prices of imported microcapsules for brachytherapy on the basis of the isotope iodine-125 in 2007-2015, $/EA.

    Figure 21: Dynamics of export of water from 97,0% of the isotope 18O Russia in 2007-2015, kg

    Figure 22: Export price of water 97,0% of the isotope oxygen-18 in 2007-2015, thousand $ /kg

    Figure 23: Dynamics of average annual export prices on raw isotope cobalt-57 in the chloride form and the product "gamma source", thousand $/Key

    Figure 24: Dynamics of export of raw materials and isotopic sealed sources based on 60Co Russia in 2007-2015, mln CI/g

    Figure 25: Dynamics of Russian import of radiation sources based on 60Co for medical gamma settings in 2007-2015, thousand CI/g

    Figure 26: Dynamics of exports of primary isotope lutetium-177 production RIAR and IMR in 2007-2015, Ki

    Figure 27: Export prices of isotope manganese-54 RIAR production in 2007-2015, thousand $/Key

    Figure 28: export Structure of molybdenum-99 countries of destination in 2015, %

    Figure 29: Dynamics of Russian exports and import of molybdenum-99 in 2007-2015, Ki

    Figure 30: Dynamics of import (from South Africa) and average export prices of the Russian Federation for molybdenum-99 in 2007-2015, $/Key

    Figure 31: Export prices of molybdenum-99, supplied RIAR, Institute of physical chemistry and in 2015, $/Key

    Figure 32: Dynamics of Russian export and import of compounds with the carbon-13 isotope in 2007-2015, kg

    Figure 33: Export price on carbon dioxide enriched in 13C over 99% of production of JSC "PA Electrochemical plant" in 2007-2015, thousand $ /kg

    Figure 34: Average annual export prices on raw isotope carbon-14 production AT the "Mayak" and JSC "Institute of reactor materials" in 2007-2015, thousand $/Key

    Figure 35: Dynamics of export prices for the isotope cesium-131 production IWW and RIAR in 2007-2015, thousand $/Key

    Figure 36: Dynamics of export of sealed sources with cesium-137 production "Mayak" in 2007-2015, thousand Ki

    Figure 37: Forecast of production of isotopes for medical purposes in Russia in 2016-2025, billion RUB

    Figure 38: Forecast of production of isotope products for medical purposes (RFP, generators, isotopes, radiation sources, calibration sources, working gases for MRI) in Russia in 2016-2025, billion RUB

     

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